The 41-year-old cyclist was stripped of the seven Tour de France titles he picked up between 1999 and 2005, and banned from competitive cycling for life by officials at the U.S. Anti-Doping Agency last year (12) over claims of illicit performance-enhancing drug use.
The controversy hit headlines around the world and prompted the star to step down from his role as the head of his cancer charity the Lance Armstrong Foundation.
Armstrong remained largely silent about the scandal, but has now agreed to talk to Winfrey in an interview for her OWN network.
A statement from the media mogul's company reads, ""Oprah Winfrey will speak exclusively with Lance Armstrong in his first no-holds-barred interview. Armstrong will address the alleged doping scandal, years of accusations of cheating, and charges of lying about the use of performance-enhancing drugs throughout his storied cycling career.""
The chat will air in the U.S. on 17 January (13).